Yael Gothelf, PhD

VP SCIENTIFIC AND REGULATORY AFFAIRS
Dr. Yael Gothelf has over fifteen years’ experience in the biotechnology industry. At Cell-Gene company, she is responsible for regulatory compliance, clinical trials, product development, and intellectual property.
Before joining the company in 2007, she was the Scientific Manager of the Research and Process Development Division of InterPharm Laboratories, Israel, a subsidiary of Ares-Serono. Prior to that, she was a researcher at the Molecular and Cell Biology Department of the Weizmann Institute of Science, where she also completed her postdoctoral fellowship.
Dr. Gothelf holds a PhD from Tel Aviv University.
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Hi
Here you can see some frequently asked questions or contact us!

What passage are your cells?

Our human mesenchymal stem/stromal cells (hMSCs) are provided at a population doubling level (PDL) of 8-10 post-mononuclear isolation (Bone Marrow; Equivalent Passage 2) or 14-18 post-isolation from the perivascular region of Wharton’s Jelly (Umbilical Cord; Equivalent Passage 3). Due to variabilities of seeding and harvest densities we characterize our MSC “True Age” in terms of their PDL.

How often should I feed your cells?

A: There is no need to feed cells between passages. Our media is engineered to be a batch culture media, where no media exchange or feed is necessary when following our suggested protocols.

Are your vials sold from pooled donors?

No, we do not pool donors at any time during our production. Master Cell Banks (MCBs) are created from each donor source. Working Cell Banks (WCBs) are produced from our MCBs for general product sales.

What characterization do you provide for your hMSCs?

We characterize our hMSCs by following ISCT criteria: cell identity (surface marker expression), functional potency (angiogenic cytokine and IDO secretion), and trilineage differentiation (adipo-, osteo-, and chondrogenesis). This information is provided to allow customers to choose the optimal hMSC tissue type and donor for their specific application or target indication.